In a US multicenter electronic health record study, researchers compared tirzepatide with semaglutide in adults with asthma and type 2 diabetes, matching 8,176 patients in each treatment group. Asthma exacerbation risk was similar between treatments, while tirzepatide was associated with a lower likelihood of receiving a short-acting beta-agonist prescription.

A pooled analysis of individual data from five time-restricted eating trials involving 124 adults linked shorter eating windows with modestly greater weight loss. Eight-hour TRE was associated with greater weight loss than 12-hour TRE and controls, while cardiometabolic outcomes showed no consistent relationship with eating-window duration and several weight associations weakened after adjustment.

A national analysis of 6,166 US hospitals found that specific workflow AI capabilities were associated with higher sepsis bundle completion rates and lower 30-day pneumonia mortality, whereas robotics showed narrower procedural associations. Geographic access remained highly uneven, with about 114.6 million people in the access-analysis population living more than 30 minutes from an AI-enabled hospital, although the observational design prevents causal conclusions.

In pooled prospective data from 977,282 UK adults, preferring tea or coffee “very hot” was associated with more than threefold higher risk of esophageal squamous cell carcinoma compared with preferring drinks “warm,” while drink temperature showed no material association with adenocarcinoma risk. Consuming six or more hot drinks daily was independently associated with higher squamous cell carcinoma risk, and modeling estimated that about 440 UK cases each year could be prevented by switching from “very hot” to “hot” drinks if the association is causal.

In a cross-sectional analysis of more than 4.2 million summer outpatient encounters across US community health centers, same-day extreme heat was associated with small reductions in systolic and diastolic blood pressure, with somewhat larger differences among adults aged 65 years or older. The changes were unlikely to be clinically meaningful for most individuals, suggesting that acute blood pressure shifts may account for little of the cardiovascular risk associated with extreme heat.